CRISPR genetically-modified girls ‘given ENHANCED brains’, warn scientists
CRISPR genetically-edited Chinese twins may have had their minds enhanced, scientists have warned.
Article via Express
Modern medicine has worked miracles in improving the quality and length of life. And science’s influence in medical matters could well accelerate soon, if CRISPR’s immense potential is harnessed. But news that twins in China had their genes modified before birth, in a premature case of human experimentation, shocked the world.
CRISPR holds extraordinary promise for treating and preventing a wide range of diseases, from cancer, heart disease and even mental illness.
But ethical concerns have been made about the use genome editing, in addition to fears CRISPR could be misused or even transformed into the next generation of biological weapon.
Such ethical concerns appeared validated after news broke in January about two genetically edited girls born in China.
And a leading scientist has now voiced fears the genetically modified babies may have had their brains changed.
Twins Lulu and Nana were thought to have had their genes modified before birth by a Chinese scientific team using the CRISPR editing tool.
The goal was to make the girls immune to infection by HIV, the AIDS causing virus.
And new research shows that the same alteration introduced into the girls’ DNA, deletion of a gene called CCR5, could be linked to greater success in school.
Alcino J. Silva, a neurobiologist at the University of California said: “The answer is likely yes, it did affect their brains.”
“The simplest interpretation is that those mutations will probably have an impact on cognitive function in the twins,” says Silva.
He says the exact effect on the girls’ cognition is impossible to predict, and “that is why it should not be done.”
The Chinese team, led by He Jiankui of the Southern University of Science and Technology in Shenzhen, claimed it had controversially used CRISPR to delete CCR5 from human embryos, some of which were later used to create pregnancies.
HIV requires the CCR5 gene to enter human blood cells.
The CRISPR experiment was widely condemned as irresponsible, and He is under investigation in China.
News of the first gene-edited babies also fuelled the debate whether CRISPR technology could one day be used to create super-intelligent humans, perhaps as part of a biotechnology race between the US and China.
There is no evidence that He actually set out to modify the twins’ intelligence.
It is understood the controversial Chinese scientist never reached out to researchers studying the effects of CCR5 on cognition, as he did to others from whom he hoped to get scientific advice or support.
“As far as I know, we never heard from him,” says Miou Zhou, a professor at the Western University of Health Sciences in California.
Although He never consulted the brain researchers, the Chinese scientist was certainly aware of the link between CCR5 and cognition.
It was first shown in 2016 by Zhou and Silva, who found that removing the gene from mice significantly improved their memory.
The team had looked at more than 140 different genetic alterations to find which made mice smarter.
Silva says because of his research, he sometimes interacts with figures in Silicon Valley and elsewhere who have, in his opinion, an unhealthy interest in designer babies with better brains.
This is why, when the birth of the twins began to make headlines, Silva says he immediately wondered if it had been an attempt at this kind of alteration.
“I suddenly realised holy s**t, they are really serious about this b******t,” says Silva.
“My reaction was visceral repulsion and sadness.”
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Bravo Greenlights Reality Show With B Smith’s Husband & Mistress!!
Bravo has just greenlit a new reality show star legendary Black model B Smith, her husband Dan Gasby, and his mistress Alex Lerner.
According to an EXTREMELY RELIABLE insider, former Real Housewives Of Atlanta producer Carlos King has signed on to produce a reality show for Dan, B, and Alex – and Bravo has already GREENLIT THE PROJECT.
The show, the snitch tells MTO News, will follow the life of B Smith, Dan and Alex- and will focus on, “The fabulous life of Alex and Dan, and how they lovingly take care of B Smith.”
Dan and his new mistress Alex will reportedly live the high life – splitting their time between NYC and The Hamptons. And B Smith will be “lovingly cared for” by the couple.
Producer/creator Carlos King is known for bringing the BEST reality shows on television – all of his shows are FULL of drama and VERY messy.
B. Smith, 69, was a millionaire, a top model, a restauranteur, and a TV personality – many referred to her as the Black Martha Stewart. But her life took a turn for the worse 10 years ago, when she was diagnosed with early onset Alzheimer’s disease.
Since then, her husband of 27 years, Dan Gasby, a former TV executive, has been caring for her. In 2016, the couple wrote a book about the early stages of Alzheimer’s titled “Before I Forget: Love, Hope, Help, and Acceptance in Our Fight Against Alzheimer’s.”
Last year Dan Gasby, 64, did something that many think is unthinkable. He started openly carrying on a relationship with a White woman, 53-year-old Alex Lerner .
All the while, his wife B Smith continues to deteriorate mentally.
Many fans of B. Smith are upset with what Dan and Alex are doing. The fans believe that it is disrespectful for Dan to openly date his girlfriend and constantly post to his social media images of the girlfriend and B. Smith as she battles her heartbreaking disease.
The show, we’re told, will explore those issues.
This is an MTO News EXCLUSIVE report.
Via: https://mtonews.com/bravo-greenlights-reality-show-with-b-smiths-husband-mistress
Women ‘are forced to have sex in return for Ebola jabs’ in the Democratic Republic of the Congo as death toll from latest outbreak passes 500
Article via DailyMail
- Latest Ebola outbreak in Democratic Republic of the Congo has killed over 500
- Officials said a vaccination programme has prevented thousands more deaths
- There are claims that some individuals have been demanding sexual favours in return for treatment for the deadly disease
Women are being forced to have sex in return for Ebola vaccinations in the Democratic Republic of the Congo, it has been claimed.
Fears of exploitation by frontline workers in the fight against the deadly disease were also highlighted as the death toll from the latest outbreak in the country passed 500.
The claims surfaced just days after the DRC’s health minister said a vaccination programme has prevented thousands more deaths.
According to The Guardian, studies have revealed concerns by ‘multiple respondents’ that some people are asking for sexual favours in return for Ebola treatments – including vaccinations.
The matter was raised as officials gathered for a national taskforce meeting in the city of Beni.
They were told how research by NGOs had found there was widespread mistrust in health workers in DRC.
On Saturday, officials revealed that more than 500 people had died from the latest outbreak of Ebola in the country, but a vaccination programme had prevented thousands more deaths.
‘In total, there have been 502 deaths and 271 people cured,’ said a health ministry bulletin, reporting on the outbreak in the east of the country.
Read more on DailyMail to learn more
FDA: Breast implants cancer warning
Article via Fortune
The United States Food and Drug Administration (FDA) issued a statement on Wednesday about the seriousness of the known link between breast implants and a rare cancer, anaplastic large cell lymphoma (ALCL). At least 457 women in the U.S. have been diagnosed with breast implant-associated lymphoma, also referred to as BIA-ALCL, and nine of those women have died. The FDA is basing these numbers on medical device reports related to ALCL that it has received since 2010.
Officials at the FDA wrote, “We hope that this information prompts providers and patients to have important, informed conversations about breast implants and the risk of BIA-ALCL.” Despite being associated with implants, ALCL is not breast cancer. It is a rare blood cancer, a non-Hodgkin’s lymphoma, and can spread throughout the body. As a supplement to its Wednesday statement, the FDA also published a letter asking health care providers to continue to report possible cases of breast cancer-related ALCL to the agency.
The FDA first sounded the alarm on BIA-ALCL back in 2011. The World Health Organization has noted that since the link was identified two decades ago, ALCL has been linked with both implants saline- and silicone-filled implants.
Additionally, implants are linked to a heightened risk of developing ALCL regardless of whether they are smooth or textured. In November, a renewed investigation into the link between textured breast implants and the rare lymphoma forced several companies that manufacture textured implants, including Allergen and Mentor, to state that despite risks, they would not cease production. The companies urged physicians to continue to inform patients of potential risks associated with the implants.
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Baltimore picked for federal program to help eradicate HIV/AIDS
Article via BaltimoreSun
Baltimore is one of dozens of hotspots the federal government plans to target as it aims to drastically reduce HIV and AIDS nationwide during the next decade, according to the U.S. Department of Health and Human Services.
The city, along with Montgomery and Prince George’s counties, is among the areas where the federal health department estimates about half of new HIV cases occur — including 48 of some 3,000 counties nationwide, seven states, Washington, D.C., and Puerto Rico. The department plans to direct funding to those areas to boost resources for fighting HIV and AIDS.
But the day after President Donald Trump announced the initiative in his State of the Union address, neither the Maryland Department of Health nor the Baltimore City Health Department had received details about how the initiative might be implemented locally.
The program was among the public health goals Trump mentioned in his State of the Union address Tuesday.
“In recent years we have made remarkable progress in the fight against HIV and AIDS,” Trump said. “Scientific breakthroughs have brought a once-distant dream within reach. My budget will ask Democrats and Republicans to make the needed commitment to eliminate the HIV epidemic in the United States within 10 years. Together, we will defeat AIDS in America.”
While Trump spoke of eliminating HIV within 10 years, the program’s actual goals are to reduce new HIV infections by 75 percent in five years and 90 percent in a decade, according to a statement posted by Health and Human Services Secretary Alex Azar.
Maryland ranked fifth of all U.S. states and territories in HIV diagnosis rates, with 20.4 diagnoses per 100,000 people in 2017, according to data from the state health department and the Centers for Disease Control and Prevention.
Baltimore City and Prince George’s County had the highest diagnosis rates in the state that year. In Baltimore, the rate of new HIV diagnoses among patients age 13 and older was 44.7 per 100,000 people in 2017, according to the city health department.
In Baltimore, 231 new HIV cases were diagnosed in 2017, the most recent year for which data were available, said Dr. Adena Greenbaum, assistant commissioner of the clinical services and HIV/STD prevention for the Baltimore City Health Department. She said the city already surpassed its goal of a 25 percent reduction in annual HIV diagnoses between 2010 and 2020.
More than 12,000 people are living with HIV in the city, she said. Statewide, there were 30,566 adults or adolescents living with HIV at the end of 2017, according to state health department data.
Federal health officials analyzed data on the spread of HIV to identify the counties with the highest number of new HIV diagnoses and states with high rates of HIV in rural areas, according to information from the department. The initiative will provide funding to those jurisdictions in phases, “starting with the areas with the highest burden,” according to the federal health department.
The Maryland Annual HIV Epidemiological Profile for 2017 estimated 11.6 percent of people living with HIV in Maryland had not been diagnosed.
Of those people who were diagnosed with HIV in Baltimore, about 73 percent were men, 24 percent were women and 3 percent identified as transgender according to Greenbaum. About 80 percent of those patients were black, 13 percent were white and 3 percent were Hispanic. And 37 percent of all the new cases were diagnosed in people younger than 30, she said.
“HIV does not affect all communities equally. That’s true nationwide and it’s also true in Baltimore, and there are those who are disproportionately affected by HIV,” Greenbaum said. “We cannot address HIV without reducing disparities and reducing health inequities.”
The city health department already offers free HIV testing, works with community groups and clinics to reduce the stigma around HIV and AIDS, and is aiming to increase access to a pill that can prevent HIV infection for people who are exposed to the virus. The department also works to link HIV and AIDS patients with health care providers by making appointments and arranging transportation for them.
“We would certainly welcome any additional resources that were available to Baltimore City to be able to increase our efforts surrounding HIV prevention and treatment,” Greenbaum said.
The federal health department said it plans to meet with community members to develop plans tailored to communities in the program and ensure the initiative is meeting their needs.
While Trump spoke of wiping out HIV in 10 years, the program’s actual goals are to reduce new infections by 75 percent in the next five years and by 90 percent in a decade.
Azar said the initiative would increase investments to existing programs in geographic hotspots, establish a new program through community health centers to provide medicine to protect persons at highest risk, use data to target services and fund the creation of a local HIV HealthForce in these targeted areas.
The proposal was met with a mix of skepticism and cautious optimism by activists in the fight against AIDS. And state and local health officials warned the administration not to take money from other programs to finance the initiative.
“This effort cannot move existing resources from one public health program and repurpose them to end HIV without serious consequences to our public health system,” said Michael Fraser, CEO of the Association of State and Territorial Health Officials, in a statement.
While Trump spoke of wiping out HIV in 10 years, the program’s actual goals are to reduce new infections by 75 percent in the next five years and by 90 percent in a decade.
Azar said the initiative would increase investments to existing programs in geographic hotspots, establish a new program through community health centers to provide medicine to protect persons at highest risk, use data to target services and fund the creation of a local HIV HealthForce in these targeted areas.
The proposal was met with a mix of skepticism and cautious optimism by activists in the fight against AIDS. And state and local health officials warned the administration not to take money from other programs to finance the initiative.
“This effort cannot move existing resources from one public health program and repurpose them to end HIV without serious consequences to our public health system,” said Michael Fraser, CEO of the Association of State and Territorial Health Officials, in a statement.
It’s unclear how much the federal program will cost. Funding for the initiative, in addition to investments in current efforts to fight HIV/AIDS, is expected to be part of Trump’s budget request for fiscal 2020.
AIDS activists said they’re ready to work with the White House but also wary because of Trump’s previous efforts to slash Medicaid, the health insurance program for low-income people, and his administration’s ongoing drive to roll back newly won acceptance and rights for LGBTQ people.
“To date, this administration’s actions speak louder than words and have moved us in the wrong direction,” said AIDS United, which funds and advocates policies to combat AIDS.
The Associated Press contributed to this article.
Tyson recalls chicken nuggets over rubber contamination
Article via CBSNews
Tyson Foods is recalling more than 36,000 pounds of chicken nuggets because they may be contaminated with small pieces of rubber.
The U.S. Agriculture Department says there were consumer complaints about extraneous material in 5-pound packages of Tyson White Meat Panko Chicken Nuggets. There are no confirmed reports of adverse reactions.
“A small number of consumers contacted the company to say they had found small pieces of soft, blue plastic in the nuggets, prompting the company to issue the recall,” Tyson said in a statement.
It added that the pieces were found “in a very small number of packages” and that no injuries had been reported.
Tyson said the nuggets were shipped to “club store distribution centers in Arizona, California, Illinois, New Jersey and Utah.”
The packages have a best if used by date of Nov. 26, 2019 and the case code 3308SDL03. The establishment core P-13556 is inside the USDA inspection mark.
The nuggets should be thrown out or returned to the place of purchase.
Officials in anti-vaccination ‘hotspot’ near Portland declare an emergency over measles outbreak
Article via WashingtonPost
A quickly escalating measles outbreak around Portland, Ore., has led health officials in nearby Clark County, Wash., to declare a public health emergency as they warn that people infected with the highly contagious virus have visited schools and churches, a dentist’s office, a Costco, an Ikea and an Amazon locker pickup station.
Someone with measles was at Concourse D of the Portland International Airport on Jan. 7, the county’s public health department advised. An infected person attended a Portland Trail Blazers home game Jan. 11.
At the beginning of last week, there were only a handful of confirmed cases. On Friday, the day the emergency was declared, there were 19. By Sunday, that number had grown to 21. The latest update came Tuesday, when county officials said they had confirmed 23 cases and were investigating two more suspected cases. The vast majority of those who have fallen ill had not been immunized.
The outbreak makes concrete the fear of pediatric epidemiologists that a citadel of the movement against compulsory vaccination could be susceptible to the rapid spread of a potentially deadly disease.
“It’s alarming,” Douglas J. Opel, a pediatrician at Seattle Children’s Hospital, said in an interview with The Washington Post. “Any time we have an outbreak of a disease that we have a safe and effective vaccine against, it should raise a red flag.”
State data shows that 7.9 percent of children in Clark County were exempt in the 2017-2018 school year from vaccines required for kindergarten entry, which includes the two-dose course for measles that the Centers for Disease Control and Prevention says is 97 percent effective. Only 1.2 percent of the children had a medical dispensation, meaning that nearly 7 percent were not immunized for personal or religious reasons. Nationally, about 2 percent of children went without required immunizations for nonmedical reasons.
The high rate of nonmedical exemption for vaccines is what makes the Portland area, which sits across the Columbia River from Clark County, a “hotspot” for outbreaks, according to Peter J. Hotez, a professor of pediatrics and dean of the National School of Tropical Medicine at Baylor College of Medicine in Houston.
“This is something I’ve predicted for a while now,” he said of the public health emergency in Clark County. “It’s really awful and really tragic and totally preventable.”
Of the confirmed cases, 18 patients are between the ages of 1 to 10 years old. Twenty of the infected individuals had not been immunized against measles, and the vaccination history of the other three remained unverified. One person was hospitalized.
Experts advised that the outbreak could still be in its infancy. The incubation period of the virus averages two weeks, and it can be spread four days before a rash makes its onset obvious.
Because measles is among the most highly contagious of all infectious diseases, it is bound to flare up in areas with low vaccination rates, Hotez said. He tracked this effect in a paper last year in the Public Library of Science, linking the number of philosophical exemptions, which has climbed since 2009 in 12 of the 18 states that allow them, to increasing outbreaks.
The problem is especially pronounced, the paper found, in more than a dozen “hotspot metropolitan areas,” including Portland and Seattle in the Northwest, Phoenix in the Southwest and Detroit in the Midwest.
Public health experts are sounding alarms about the geographical clustering of people who refuse to immunize themselves, which creates vulnerabilities despite the overall high rate of vaccination. In November, Asheville, N.C., another stronghold of the anti-vaccination movement, succumbed to the state’s worst chickenpox outbreak since a vaccine for the infection became available more than two decades ago.
“Portland is a total train wreck when it comes to vaccine rates,” Hotez said in an interview with The Post.
Opposition to compulsory vaccination in the Pacific Northwest dates to the Progressive Era and continues despite major medical breakthroughs. The modern anti-vaccination movement — built on debunked research published in 1998 that associated the vaccine for measles, mumps and rubella, known as the MMR vaccine, with autism — is not exclusive to one side of the political divide, survey data suggests; it tends to find its most fervent supporters at both extremes.
Measles is a dire price to pay for leniency about vaccination, Hotez cautioned, calling the illness “one of the most serious infectious diseases known to humankind.” After smallpox was eradicated in 1980, measles became the leading killer of children globally, he said.
Read more via WashingtonPost
Anti-vaxxers are among the WHO’s top 10 global health threats, and Ebola fake news is killing people
During an outbreak in the Democratic Republic of Congo, “as rumors surface, communications experts rebut them with accurate information via WhatsApp or local radio.”
Anti-vaxxers are one of the top 10 global health threats. The World Health Organization identified “vaccine hesitancy” — “the reluctance or refusal to vaccinate despite the availability of vaccines” — as one of its top 10 health concerns facing the world in 2019.
A 2018 study found that “philosophical-belief” vaccine non-medical exemptions have risen in 12 of the 18 states that allow them, and the authors noted:
While NMEs continue to rise in most of the 18 US states that allow them, several European countries, including France and Italy, as well as Australia, have taken measures to either make vaccines compulsory or even fine parents who refuse to vaccinate their children. Romania has experienced serious and large measles outbreaks and may also tighten vaccine legislation. Our concern is that the rising NMEs linked to the antivaccine movement in the US will stimulate other countries to follow a similar path. It would be especially worrisome if the very large low- and middle-income countries — such as Brazil, Russia, India, and China (the BRIC nations), or Bangladesh, Indonesia, Nigeria, and Pakistan — reduce their vaccine coverage. In such a case, we could experience massive epidemics of childhood infections that may threaten achievement of United Nations global goals.
Measles cases in Europe are at a 20-year high, The Guardian reported last month, topping 60,000 in 2018 per WHO — “more than double that of 2017 and the highest this century. There have been 72 deaths, twice as many as in 2017.” New York is facing its most severe measles outbreak in decades, with cases there concentrated almost exclusively among ultra-Orthodox Jews.
This week, Elsevier Atlas highlighted research that aims to help explain anti-vaccine attitudes. The study looked at the Dunning-Kruger effect — a form of cognitive bias in which people assume they know more than they actually do about an issue, or people’s “ignorance of their own ignorance” — surrounding vaccines. Matthew Motta, a postdoc at the Annenberg Public Policy Center at the University of Pennsylvania and is the lead author of of the study, explained:
We gave people a knowledge test about the causes of autism and then we asked people in a national survey: How much do you think you know about the causes of autism? We asked the same question about medical experts like doctors and scientists. We compared people’s perceptions of self to perceptions of experts and looked at that versus how well they scored on the knowledge test. We show there’s a relationship between knowledge and misinformation and what we call overconfidence — the belief that you know more. As we showed, those who are the least knowledgeable and most misinformed were most likely to exhibit overconfidence. Once we did that, we looked at policy implications of overconfidence. We looked at the correlation between attitudes, for example, about whether it should be required to vaccinate kids going to public school. Those who were the most overconfident were less likely to think that was the case.
The researchers, in a survey of 1,300 U.S. adults, found that “more than a third of study participants believe they knew as much as or more than medical doctors and scientists about the causes of autism,” and that while they trusted information from experts, they also “place high levels of trust on information from non-experts (42 percent) and feel that non-experts should play a major policymaking role (38 percent).”
“We need efforts to inform people, but we also need to debunk misinformation. Hitting people over the head with facts probably isn’t going to do that,” Motta said. “What it might look like is the subject of follow-up studies. That’s the key question: how can we combat misinformation about vaccines?”
“More transparent — in some cases literally.” In Science Magazine, author and science journalist Laura Spinney reports on how rumors and hoaxes are making the battle against an Ebola outbreak in the Democratic Republic of Congo more difficult — and how public health workers have launched an unprecedented effort to fight misinformation.
For the first time in an Ebola outbreak, UNICEF and other agencies have joined forces as a single response team, which answers to the DRC’s Ministry of Health and includes dozens of social scientists, who use the airwaves, social media, and meetings with community and religious leaders to fight misinformation. Responders also foster trust by making their work more transparent — in some cases literally. A new biosecure tent, called the Biosecure Emergency Care Unit for Outbreaks (CUBE), allows relatives to visit and see Ebola patients during treatment.
Here’s some of what the social scientists are doing:
Part of their role is to chart the social networks through which the virus spreads, but they also gather information about communities’ perceptions, which is entered within days into an online “dashboard” created by the International Federation of Red Cross and Red Crescent Societies (IFRC) in Geneva. The government has also recruited young people to report misinformation circulating on WhatsApp, a major information channel in the DRC, says Jessica Ilunga, a spokesperson for the DRC’s Ministry of Health in Kinshasa.
As rumors surface, communications experts rebut them with accurate information via WhatsApp or local radio. They take care not to repeat the misinformation; research has shown this is the best way to help the public “forget” false news and reinforce the truth. The vocal support of Ebola survivors has helped as well. Grateful for their care, some have become volunteers at Ebola treatment centers (ETCs).
And the BBC’s Yvonne McPherson, director of BBC Media Action USA, wrote in December about her work as BBC Media Action’s Ebola response efforts. There’s a difference, she explains, between “acute and chronic misinformation problems.” An example of an acute misinformation problem, for instance, was a 2014 rumor that you could avoid Ebola by bathing in salt water.
The salt water Ebola example was a real life case of acute misinformation in West Africa. News reports tracked this rumor to a text message from a student in Nigeria. It spread immediately to social media, with hundreds of tweets repeating the rumor in the following couple of days. In just as many days, the Nigerian Ministry of Health, the World Health Organization and others corrected it across traditional and social media, and the rumor was quashed. Sadly, this misinformation was responsible for at least two deaths and many people were hospitalized due to excessive consumption of salt water.
That’s an acute scenario: where misinformation spreads rapidly, then is corrected by multiple trusted sources and goes away.
But chronic misinformation is even trickier:
A chronic misinformation example would be the belief or suspicion that vaccines are harmful. It is chronic because this misinformation persists over years despite available facts to the contrary.
Algorithms, and the market forces underpinning them, are designed to capture attention, and in turn provide a breeding ground for misinformation to spread. Tweaking algorithms to direct people away from non-credible sources or annotating articles with credibility warnings may be part of a solution; however, these efforts do not address the longstanding beliefs people may already have about a health issue.
Article via niemanlab.org